Frank R. Schmidt

Postdoctoral Researcher


White Matter MS-Lesion Segmentation Using a Geometric Brain Model

Maddalena Strumia, Frank R. Schmidt, Constantinos Anastasopoulos, Cristina Granziera, Gunnar Krueger, Thomas Brox
IEEE Transactions on Medical Imaging, Volume 35, Number 7, page 1636 - 1646 - Jul 2016
Download the publication : 3.1 MB 
Brain magnetic resonance imaging (MRI) in patients with Multiple Sclerosis (MS) shows regions of signal abnormalities, named plaques or lesions. The spatial lesion distribution plays a major role for MS diagnosis. In this paper we present a 3D MS-lesion segmentation method based on an adaptive geometric brain model. We model the topological properties of the lesions and brain tissues in order to constrain the lesion segmentation to the white matter. As a result, the method is independent of an MRI atlas.
We tested our method on the MICCAI MS grand challenge proposed in 2008 and achieved competitive results. In addition, we used an in-house dataset of 15 MS patients, for which we achieved best results in most distances in comparison to atlas based methods. Besides classical segmentation distances, we motivate and formulate a new distance to evaluate the quality of the lesion segmentation, while being robust with respect to minor inconsistencies at the boundary level of the ground truth annotation.

Images and movies

teaser.png (170 KB)

BibTex references

  author       = "Strumia, Maddalena and Schmidt, Frank R. and Anastasopoulos, Constantinos and Granziera, Cristina and Krueger, Gunnar and Brox, Thomas",
  title        = "White Matter MS-Lesion Segmentation Using a Geometric Brain Model",
  journal      = "IEEE Transactions on Medical Imaging",
  number       = "7",
  volume       = "35",
  pages        = "1636 - 1646",
  month        = "Jul",
  year         = "2016",
  url          = ""